Saturday, January 30, 2016

Video: Neuroregeneration

The Neuroregeneration Program at Johns Hopkins’ Institute for Cell Engineering

Published on Mar 27, 2015

Researcher Valina Dawson introduces the Neuroregeneration Program, where scientists study causes and potential treatments for conditions such as Parkinson’s and stroke. For more information, visit Hopkins Medicine - Neuroregeneration.

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Neurology - Nerve Damage and Regeneration

Published on Dec 8, 2014

Standard YouTube License @ Armando Hasudungan

WMIF 2015 | Regeneration, Cell Therapy, and Neurocare: Products? Delivery?

Published on Jun 3, 2015

SSTattler: Take 56 minutes and they talk about "Expert panel members discuss CNS (central nervous system) therapies that use healthy cells, tissues or organs — or those created with 3D bioprinters — to replace damaged ones." Maybe a stroke is the next possibility...? Good YouTube.

Alice Park, Writer, TIME Magazine

Ole Isacson, MD, Director, Center for Neuroregeneration Research/Neuroregeneration Laboratories, McLean Hospital; Professor of Neurology, Harvard Medical School

Martin McGlynn, CEO, StemCells

Doug Melton, PhD, Xander University Professor, Harvard University; Investigator, Howard Hughes Medical Institute; Co-Chair Department of Stem Cell and Regenerative Biology

David Scadden, MD, Director, Center for Regenerative Medicine, Massachusetts General Hospital; Gerald and Darlene Jordan Professor of Medicine, Harvard Medical School

Regenerative medicine holds the promise of healing damaged tissues and organs from within. Expert panel members discuss CNS therapies that use healthy cells, tissues or organs—or those created with 3D bioprinters—to replace damaged ones.

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Helping the Body Regrow Nerves - Science Nation

Published on Aug 22, 2013

Combat, cancer and accidents -- all can cause devastating nerve injuries. Sometimes, the body heals on its own.

SSTattler: How about stroke ???

"Your peripheral nerves, the ones in the arms and the face, have an inherent ability to regenerate, but only under ideal circumstances," says University of Florida biomedical engineer Christine Schmidt.

With support from the National Science Foundation (NSF), Schmidt and her team are working to restore nerve function when injuries are more complicated. Surgeons can sometimes move a nerve from one part of a patient's body to another. Schmidt has developed a method that grafts cadaver tissue onto the damaged area to act as a scaffold for nerves to re-grow themselves.

"This medical application has been made possible by developing new tissue engineering methods and by understanding how cells interact with their surroundings," notes Friedrich Srienc, director of the Biotechnology, Biochemical and Biomass Engineering program in NSF's Directorate for Engineering.

Schmidt and her team are also looking at other approaches to directly stimulate nerve growth using as building blocks the natural sugar molecules found in the body. That would eliminate the need to transplant tissue. While the ultimate goal in nerve regeneration is reversing paralysis, Schmidt says intermediate successes, such as improving lung or bladder function, can be invaluable to patients and their families.

The research in this episode was supported by NSF award #0829166, "Direct Write" Techniques to Create Submicron, Arbitrary Protein Structures within Hyaluronan Hydrogels; NSF award #0805298, Crystal Templated Polysaccharide Hydrogels; NSF award #9733156, CAREER: Understanding the Molecular Mechanics of Growth Cone Motility and Nerve Regeneration; NSF award #0201744, Angiogenic Hydrogel Biomaterials to Promote Nerve Regeneration; and NSF Award #0500969, Hyaluronan-based Materials and Size-dependent Mechanisms of Wound Healing.

Miles O'Brien, Science Nation Correspondent

Marsha Walton, Science Nation Producer

Standard YouTube License @ National Science Foundation

Nerve Regeneration - Everything You Need To Know - Dr. Nabil Ebraheim

Published on Dec 19, 2013

SSTattler: Nice music, no voice, but good movie...

Educational video describing the process of motor neuron injury and regeneration.

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Paving the Path for Nerve Regeneration

Uploaded on Oct 1, 2010

Peripheral nerves are able to regrow and regenerate following injury. Watch as Alison Lloyd and her colleagues take you on a brief, personally guided tour of their new discovery for how Schwann cells, instructed by ephrin signaling from fibroblasts, pave a path that guides the regeneration of peripheral axons.

Standard YouTube License @ cellvideoabstracts

Project 71 - Microstructure Imaging of Nerve Regeneration Network

Published on Jun 30, 2015

The clinical problem: Nerve injuries can be debilitating for patients, resulting in long term loss of sensation and power and control of movement and the possibility of chronic pain. A variety of microsurgical approaches are used to repair damaged nerves, however there are only clinical surrogates available to assess and quantifying the speed and extent of nerve regeneration following injury. Current techniques tend to be limited to indirect measures of response to mechanical stimulation (a clinical sign known as Tinel’s sign), and predictions based on crude estimates of neuronal growth rate.

The aim of the project: This project aims to develop a cutting-edge microstructure imaging techniques to visualize in-vivo and non-invasively the growth of the neurons in the peripheral nerve system (PNS). Microstructure imaging techniques involve a combination of Diffusion MRI, mathematical models of nerve tissue and computational methods for sequence optimisation and parameter estimation. They can quantify neuronal regeneration using microstructure indices such as axonal diameter, density and orientation.

The proposed methodology: The project will firstly develop novel diffusion MRI techniques to study PNS tissue microstructure. For this it will develop a mathematical model of PNS tissue and then use sophisticated computational methods to optimize diffusion MRI sequences for sensitivity to the parameters of that model, such as axon diameter and density, which are crucial when assessing nerve damage and regeneration. The project will then apply these new techniques of microstructure imaging to a group of patients with upper limb peripheral nerve injuries under the care of the Peripheral Nerve Injury Unit of the Royal National Orthopaedic Hospital (RNOH). This will allow investigation of how axonal properties change throughout the process of regeneration and investigate the characteristics of neuronal regeneration. Further, the study will correlate these imaging findings with clinical markers and relate these to the functional ability of the arm, and estimate conduction delay, the key parameter that links microstructure and nerve function. Finally, it will evaluate different methods for nerve regeneration and repair.

Feasibility: Previous research has shown that Diffusion MRI of the PNS can be done with very good quality. Furthermore, we have shown recently in simulation (Drobnjak et al MRM 2015) and experimentally (Shrestha et al ISMRM 2014) that clinical scanner can image the sizes of axon diameters present in PNS.

Impact: Novel methodology will make a strong impact in monitoring and quantifying the extent of nerve regeneration following injury. That can lead to improved surgery performance and improved rehabilitation methods. Furthermore, understanding the nerve regeneration networks will contribute in developing better methods for nerve regeneration and repair.

Filmed and produced by

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KUSI Interview with Dr. Justin Brown, MD Neurosurgeon on Nerve Regeneration Breakthrough

Published on Jun 14, 2012

This news segment featured on KUSI in San Diego was aired in June, 2012. It features Dr. Justin Brown, neurosurgeon who specializes in nerve regeneration and extremity reanimation. This medical breakthrough restores movement to paralyzed areas of the body by reconnecting nerves that work to muscles that do not.

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Stem Cells and Neuroregeneration

Uploaded on May 11, 2011

SSTattler: It takes 51 minutes...

2008 Rare Neuroimmunologic Disorders Symposium, Stem Cells and Neuroregeneration, Douglas A. Kerr, MD, PhD

Transverse Myelitis Association

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